Baked-on siliconisation for prefillable syringes

Today, many of the new drugs developed by the pharmaceutical industry demand increasingly individual packaging approaches to meet specific requirements. Special finishing processes to ensure compatibility of the packaging material with the active substance in the drug product hold it stable in solution and prevent it becoming inactive.

In the production of syringe systems at Gerresheimer Bünde, certain processes such as baking of silicone oil on the inside of the syringe barrel help to stabilize sensitive biotech drugs in solution. A particular problem is that silicone oil droplets generated by conventional liquid siliconisation can under specific circumstances interact with the drug. An example of this is silicone-oil-induced protein aggregation in biotech-derived drug products, which in the worst case can lead to rejection of the drug. Our patented baked-on siliconisation (EP 1818069/US 7404278) provides the syringe barrel with a lasting, stable and even glide coating so that problem-free application is guaranteed over the whole shelf life of the drug.