Prefillable luercone glass syringes, ready-to-use, ready-to-fill
Gx® Prefillable Luer Cone Glass Syringes

Gx® bulk and Gx RTF® format

We offer an extensive portfolio of prefillable luer cone glass syringes that are adapted to the current requirements of the pharmaceutical industry and fulfill the requirements of modern filling systems. The luer cone glass syringes are available as bulk goods (Gx® bulk) or in „ready-to-fill“ format (Gx RTF®). Syringes can be provided as a complete system with plunger stopper, plunger rod and backstop. Various options for siliconization and printing complete our offer. A Drug Master File Type III is available.

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Gx® bulk and Gx RTF® format

Packaging of bulk syringes in Rondo trays
Packaging of bulk syringes in Rondo trays in clean room GMP class D

Gx® bulk prefillable luer cone syringes are washed, sterilized, and filled by the customer. For this form, there is a division of labor between the primary packaging manufacturer and the pharmaceutical industry where we provide the unsterilized glass syringe bodies in flat trays (Rondo trays). 

Packaging of Gx RTF® glass syringes in nests
Packaging of Gx RTF® glass syringes

Gx RTF® prefillable luer cone glass syringes are washed, siliconized, pre-assembled with the closure systems Six Rib Tip Cap and sterilized with ethylene oxide (EtO) by Gerresheimer Medical Systems. This means we deliver the prefillable glass luer cone syringe completely prepared for aseptic filling.

Gx RTF® syringes are packed in nests for easy handling and filling. These nests are suitable for all usual filling systems. Gx RTF® syringes are nested by:

  • 100 nest (10x10) for 0.5 ml, 1.0 ml long and 1.0 – 3.0 ml
  • 160 nest (10x16) for 0.5 ml und 1.0 ml long

Syringe sizes from 0.5 ml to 5.0 ml (bulk only), additional formats upon request

The high-quality prefillable Gx® bulk and Gx RTF® luer cone glass syringes are produced from type I glass. The prefillable luer cone glass syringes are available in syringe sizes from 0.5 ml to 5.0 ml (bulk only, individual solutions on request). The luer cone glass syringe is also available as a dual chamber syringe  in the sizes 2.25 ml and 5.0 ml (bulk only).

luer cone glass syringes
0.5 ml
47.6
6.85
4.65
1.0 ml long
54.0
8.15
6.35
1.0 ml standard
35.7
10.85
8.65
1.5 ml
43.2
10.85
8.65
2.25 ml
54.4
10.85
8.65
3.0 ml
72.2
10.85
8.65
5.0 ml (bulk only)
67.6
14.45
11.85

Closure system Six Rib Tip Cap

Six Rib Tip Cap closure system for prefillable luer cone glass syringes
Six Rib Tip Cap closure system for prefillable luer cone glass syringes

We offer a Six Rib Tip Cap as a closure system for our prefillable luer cone glass syringes.

EtO-sterilizable rubber formulas: Datwyler FM27, FM30, West 1883, 7025/65, 7028/55, other formulas available upon request.

Round and cut finger flanges

We offer the Gx® bulk and Gx RTF® prefillable luer cone glass syringes with round (small and standard) and cut finger flanges.

Prefillable luercone glass syringe with small round finger flange
Small round
Prefillable luercone  glass syringe with standard round finger flange
Standard round
Prefillable luercone glass syringe with cut finger flange
Cut

Various options for siliconization

Siliconization is critical to ensure reliable function of prefillable luer cone glass syringes. It ensures optimal syringe performance for delivering medications. Thanks to the hydrophobicity of the silicon layer, potential interaction between the glass and the drug formula is reduced. As a standard, our prefillable glass syringes are spray-siliconized using diving nozzle technology in order to ensure an even coating with the smallest possible amount of silicone. We also offer our Gx® Baked-on RTF® glass syringes, which are patented in Europe and the USA for the packaging of sensitive biotechnological medications that may interact with free silicone oil droplets. In this procedure, a silicone oil emulsion is applied to the inner surface of the syringe body and subsequently thermally fixated on the surface by heating. This significantly reduces the number of free silicone oil droplets. Despite the considerably reduced amount of silicone oil, the syringes offer reliable hydrophobic properties and especially low breakout and gliding forces that remain stable throughout the storage period.

Baked-on siliconization for prefillable glass syringes
Baked-on siliconization for the reduction of free silicone oil

Advantages of the Gx Baked-on RTF® syringe

  • Reduced interaction risk between drug formula and silicone oil 
  • Drastically reduced amount of silicone oil droplets below the visibility threshold
  • Masking and inactivation of the glass surface 
  • Long-term stable, evenly distributed, and chemically inert lubricity coating
  • Very even break loose and gliding force profile
  • Ensures optimal functionality and drug formula stability over the period of medication storage
  • Patented in Europe and USA

Various possibilities for printing

Printing of prefillable luercone glass syringes
Printing of the glass syringe body with metal-free paints

For the individual printing of the glass syringe body of the prefillable luer cone glass syringes we offer the most varied possibilities for printing such as metal-free paints, ceramic printing on glass, various designs of graduation, dose mark, various colors and other options on request.

Syringes as a complete system

Syringes with reduced tungsten content or tungsten free

Metal-free luercone glass syringes

One problem associated with syringe use is that traces of tungsten or tungsten residues can leave residue behind in the bore when the syringe cone is shaped. Especially for drug products based on biotech derived drug products, our customers therefore require prefillable luercone syringes that ideally exclude the possibility of contamination with tungsten

With the development of an innovative production technology registered for patent, we have been able to address this requirement and create a metal-free 1 ml long Gx RTF® Luer lock syringe that is ready for series production. This process can also be transferred to other Luer lock syringe sizes or to Luer cone syringes of various sizes at any time. The pin used to shape the cone with our new technology is not made of conventional tungsten or an alternative metal, but of a special ceramic. External studies confirm that we can manufacture residue-free luercone syringes for the packaging of especially sophisticated medications with this new technology.

The Fresenius Institute conducted a study confirming that no ceramic residue can be detected in the syringe. A biocompatiblity study also verifies  that the ceramic material is not cytotoxic.

The pin used to shape the cone of the metal-free glass syringes is made of a special ceramic
The pin used to shape the cone of the metal-free glass syringes is made of a special ceramic
  • The pin used to shape the cone is made of a special ceramic
  • 1 ml long Gx RTF® Luer lock syringe ready for series production
  • The process can be transferred to other Luer lock syringe sizes or to Luer cone syringes of various sizes at any time
  • The Fresenius Institute conducted a study confirming that no ceramic residue can be detected in the syringe
  • Not cytotoxic acoording to ISO 10993-5

Luercone syringes with reduced tungsten

Core of a washing machine for the cleaning of syringes in order to reduce glass and tungsten particles
Core of a washing machine for the cleaning of syringes in order to reduce glass and tungsten particles

For reducing tungsten residues for standard luercone syringes we can offer on our standard manufacturing process of syringes an additional cleaning step using a washing machine following by the forming of the glass.

Through the combination of water and ultrasonic bath, our internally developed, multi-stage treatment system thereby reduces not only the the tungsten load dramatically by 90% on average , but also brings down the load of glass particles by up to 90 percent.

Plastic syringes made of Cyclo-Olefin-Polymer (COP)

Prefillable COP needle syringes
Prefillable COP plastic syringes for avoiding tungsten residuals

A third option is the use of plastics like Cyclo Olefin Polymers (COP) as syringe material. The production process has no potential for tungsten residuals. Our prefillable syringes of COP are therefore also exceptionally well-suited for the packaging of highly sensitive medication.

Individual solutions

Development of prefillable glass syringes and components
We develop your individual prefillable luer cone glass syringe adapted to the drug formula and the application area

Our development team would be happy to work together with you to develop a distinctive luer cone glass syringe which is matched to your specific agent, area of use and company brand.

Primary packaging and drug delivery system from one source

Development of a customized auto injector made of plastics including the prefillable glass syringe
Concept development of a customized auto injector made of plastics including the prefillable glass syringe

Gerresheimer Medical Systems offers the two primary materials used in the pharmaceuticals industry: primary packaging made of glass and plastics as well as customized drug delivery systems and medical devices made of plastics. Our Center of Excellence for prefillable glass syringes and glass cartridges in Bünde is working together closely with our plastic specialists in our Technical Competence Centers in Wackersdorf (Germany), Peachtree City (USA, GA) and Dongguan City (China). In this way we can combine our know-how in the areas of glass and plastics.

This gives our customers the possiblity to develop, together with our experts for glass and plastics, a distinctive syringe, an application system or a combination product which is matched to a specific agent, area of use and company brand. One convincing example of the cooperation of our experts for syringes with our specialists for plastics is our offering of plastic syringes developed and manufactured by Gerresheimer Medical Systems.

Product catalogue

Contact
Contact us!
Rolf Kitiratschky
Sales Europe
Phone
+49 (0) 5223 164 437
Mail
Karen Kanyok
Sales USA
Phone
+1 856 405 9737
Mail
Jacky Hu
Sales Asia
Phone
+86 769 8851 7100 328
Mail