Prefillable luer lock glass syringes, ready-to-use, ready-to-fill
Gx® Prefillable Luer Lock Glass Syringes

Gx® bulk and Gx RTF® format

We offer an extensive portfolio of prefillable luer lock glass syringes that are adapted to the current requirements of the pharmaceutical industry and fulfill the requirements of modern filling systems. The prefillable luer lock glass syringes are available as bulk goods (Gx® bulk) or in „ready-to-fill“ format (Gx RTF®). Syringes can be provided as a complete system with plunger stopper, plunger rod and backstop. Various options for siliconization and printing complete our range. A Drug Master File Type III is available.

Your PLUS with Gerresheimer

Gx® bulk and Gx RTF® format

Packaging of bulk syringes in Rondo trays
Packaging of bulk syringes in Rondo trays in clean room GMP class D

Gx® bulk prefillable luer lock glass syringes are washed, sterilized, and filled by the customer. For this form, there is a division of labor between the primary packaging manufacturer and the pharmaceutical industry where we provide the unsterilized luer lock glass syringe bodies in flat trays (Rondo trays). 

Packaging of Gx RTF® glass syringes in nests
Packaging of Gx RTF® glass syringes

Gx RTF® prefillable luer lock glass syringes are washed, siliconized, pre-assembled with tip caps or the patented Gerresheimer Gx TELC® closure systems and sterilized with ethylene oxide (EtO) by Gerresheimer Medical Systems. This means we deliver the prefillable glass luer lock syringe completely prepared for aseptic filling. 

Gx RTF® syringes are packed in nests for easy handling and filling. These nests are suitable for all usual filling systems. Gx RTF® syringes are nested by:

  • 100 nest (10x10) for 0.5 ml, 1.0 ml long and 1.0 – 3.0 ml
  • 160 nest (10x16) for 0.5 ml und 1.0 ml long

Syringe sizes from 0.5 ml to 3.0 ml (additional formats upon request)

The high-quality prefillable Gx® bulk and Gx RTF® luer lock glass syringes are produced from type I glass. The prefillable luer lock glass syringes are available in syringe sizes from 0.5 ml to 3.0 ml (individual solutions on request).

luer lock glass syringes
0.5 ml
47.6
6.85
4.65
1.0 ml long
54.0
8.15
6.35
1.0 ml standard
35.7
10.85
8.65
1.5 ml
43.2
10.85
8.65
2.25 ml
54.4
10.85
8.65
3.0 ml
72.2
10.85
8.65

Various closure systems

Tip Cap for prefillable luerlock glass syringes
Tip Cap for prefillable luer lock glass syringes

Tip Cap

Mushroom

EtO-sterilizable rubber formulas:
Datwyler FM27/FM30, Stelmi 6580, West 1883, 7025/65, 7028/55, other formulas available upon request

Closure system for prefillable luerlock glass syringes
Gx TELC®: Patented integrated luer lock closure system for prefillable glass syringes

Gx TELC®

Tamper Evident Luerlock Closure

EtO-sterilizable rubber formulas:
Datwyler FM27, Stelmi 6580, West 7025/65, other formulas available upon request

Closure system for prefillable luerlock glass syringes
Gx TELC®: Patented integrated luer lock closure system for prefillalbe glass syringes

Advantages Gx TELC®

  • Patented integrated luer lock closure system 
  • Luer lock adapter with tamper-evident property
  • Convenient and intuitive opening caused by soft touch surface and easy grip design
  • No unintentional pop off
  • Manufactured of polycarbonate (Luer Lock adapter) and medical grade Thermoplastic Elastomer (sealing cap with tamper-evident flags) using two-component injection molding
  • TPE parts offer color coding of the syringe
  • Insert is made of pharmaceutical rubber like FM27, 7025, 7028, 6580 GS can be chosen
  • Specified opening and spinning forces
  • Fulfills ISO 594 requirements
  • Steam-, gamma- and EtO-sterilization possible

Round and cut finger flanges

We offer the Gx® bulk and Gx RTF® prefillable luer lock glass syringes with round (small and standard) and cut finger flanges.

Prefillable glass luerlock syringe with cut finger flange
Cut
Prefillable glass luerlock syringe with standard round finger flange
Standard round
Prefillable glass luerlock syringe with small round finger flange
Small round

Various options for siliconization

Baked-on siliconization for prefillable glass syringes
Baked-on siliconization for the reduction of free silicone oil

Siliconization is critical to ensure reliable function of prefillable luer lock syringes. It ensures optimal syringe performance for delivering medications. Thanks to the hydrophobicity of the silicon layer, potential interaction between the glass and the drug formula is reduced. As a standard, our prefillable glass syringes are spray-siliconized using diving nozzle technology in order to ensure an even coating with the smallest possible amount of silicone oil. We also offer our Gx® Baked-on RTF® glass syringes, which are patented in Europe and the USA for the packaging of sensitive biotechnological medications that may interact with free silicone oil droplets. In this procedure, a silicone oil emulsion is applied to the inner surface of the syringe body and subsequently thermally fixated on the surface by heating. This significantly reduces the number of free silicone oil droplets. Despite the considerably reduced amount of silicone oil, the prefillable syringes offer reliable hydrophobic properties and especially low breakout and gliding forces that remain stable throughout the storage period.

Advantages of the Gx Baked-on RTF® syringes

  • Reduced interaction risk between drug formulation and silicone oil 
  • Drastically reduced amount of silicone oil droplets below the visibility threshold
  • Masking and inactivation of the glass surface 
  • Long-term stable, evenly distributed, and chemically inert lubricity coating
  • Very even break loose and gliding force profile
  • Ensures optimal functionality and drug formula stability over the period of medication storage
  • Patented in Europe and USA

Various possibilities for printing

Printing prefillable glass luerlock syringes
Printing of the glass syringe body with metal-free paints

For the individual printing of the glass syringe body of the prefillable luer lock syringe we offer the most varied possibilities for printing such as metal-free paints, ceramic printing on glass, various designs of graduation, dose mark, various colors and other options on request.

Syringes as a complete system

Syringes with reduced tungsten content

Apart from silicone oil, additional substances of the prefillable luer lock syringe can interact with the active ingredient or components of the formula. For example, a tungsten pin is used to create the syringe bore in the standard glass forming process. When traces of tungsten or tungsten oxides remain in the bore area, protein-based medications may have adverse reactions in rare cases. 

Avoiding tungsten residues by using forming pins of alternative materials
Avoiding tungsten or tungsten oxides by using forming pins of alternative materials

We offer various options for reducing or entirely avoiding tungsten residues. For example, forming pins of alternative materials can be used to form the cone, in which case neither tungsten nor other metal residues remain behind in the bore. Alternatively, forming pins made of other metals/metal alloys can be used.

Avoiding tungsten oxides by integrating an additional cleaning step for prefillalbe luer lock glass syringes in the standard manufacturing process
The drum of a washing machine for the cleaning of prefillable luer lock glass syringes in order to reduce glass and tungsten particles

In addition to our standard manufacturing process we can offer a cleaning step for prefillable luer lock glass syringes following the forming of the glass using a washing machine. Through the combination of water and ultrasonic bath, our internally developed, multi-stage treatment system reduces not only the load of glass particles by up to 90 percent, but also reduces the tungsten load dramatically.

Prefillable COP plastic syringes
Prefillable COP plastic syringes for avoiding tungsten residuals

A third option is the use of plastics like Cyclo Olefin Polymers (COP) as syringe material. The production process has no potential for tungsten residuals. Our prefillable syringes of COP are therefore also exceptionally well-suited for the packaging of highly sensitive medication.

Individual solutions

Development of prefillable glass syringes and components
We develop your prefillable luer lock glass syringe adapted individually to the drug formula and the application area

Our development team would be happy to work together with you to develop a distinctive prefillable luer lock syringe made of glass which is matched to your specific agent, area of use and company brand.

Primary packaging and drug delivery system from one source

Development of a customized auto injector made of plastics including a prefillable needle syringe made of glass
Concept development of an auto injector made of plastics including the primary packaging – a prefillable needle syringe made of glass

Gerresheimer Medical Systems offers the two primary materials used in the pharmaceuticals industry: primary packaging made of glass and plastics as well as customized drug delivery systems and medical devices made of plastics. Our Center of Excellence for prefillables glass syringes and glass cartridges in Bünde is working together closely with our plastic specialists in our Technical Competence Centers in Wackersdorf (Germany), Peachtree City (USA, GA) and Dongguan City (China). In this way we can combine our know-how in the areas of glass and plastics.

This gives our customers the possiblity to develop, together with our experts for glass and plastics, a distinctive syringe, an application system or a combination product which is matched to a specific agent, area of use and company brand. One convincing example of the cooperation of our experts for syringes with our specialists for plastics is our offering of plastic syringes developed and manufactured by Gerresheimer Medical Systems.

Discuss your next syringe and medical device project with our experts for syringes and plastics!

Contact
Contact us!
Rolf Kitiratschky
Sales Europe
Phone
+49 (0) 5223 164 437
Karen Kanyok
Sales USA
Phone
+1 856 405 9737
Mike Nie
Sales Asia
Phone
+86 769 8851 7100 317